Two sample MR report
RPS26_Endothelial Cell (Endo) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.2401526 | 0.2084323 | 0.2930759 |
| Weighted median | 8 | 0.1508351 | 0.0244142 | 0.0000000 |
| Inverse variance weighted | 8 | 0.1324755 | 0.0609941 | 0.0298602 |
| Simple mode | 8 | 0.2695545 | 0.0449446 | 0.0005436 |
| Weighted mode | 8 | 0.1525930 | 0.0222554 | 0.0002406 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 92.32797 | 6 | 0 |
| Inverse variance weighted | 144.85446 | 7 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.20167 | 0.1091548 | 0.1141758 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004162 | 1.2e-06 | TRUE | 0.065937 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
